Protein Modification Reagents
Medchemexpress LLC Propargyl-PEG2-CH2COOH | 944561-46-0 | 95.0% | 202.20 | 100 MG
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Boc-NH-PEG4-C2-Boc | 2138484-13-4 | 421.53 | 25 MG
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). These molecules are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 50 MG
M-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules
Medchemexpress LLC m-PEG20-alcohol 25mg
m-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Mal-PEG36-NHS ester | 95.0% | 1923.18 g/mol | C86H159N3O43 | 5 MG
Mal-PEG36-NHS ester is a polyethylene glycol (PEG)-based bifunctional linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. Supplied for research use, it is designed for bioconjugation and PROTAC synthesis, enabling sequential coupling to thiol and amine groups.
- Maleimide and NHS ester functional groups for thiol and amine coupling.
- PEG spacer (36 units) provides flexibility and solubility.
- Molecular weight 1923.18 g/mol.
- Purity 95.0%.
- Soluble in DMSO at 62.5 mg/mL (requires ultrasonic agitation).
- Storage: pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only.
Medchemexpress LLC m-PEG4-CH2COOH | 16024-66-1 | 99.9% | 1 G
This PEG-based PROTAC linker is used in the synthesis of PROTACs. It is intended for research applications.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Purity of 99.86%
- Molecular formula C11H22O7
- Molecular weight 266.29
- Appears as a colorless to light yellow liquid
- Specific storage conditions for pure form and in solvent
- Soluble in various solvents for in vitro and in vivo studies
- Relevant for cancer and cancer targeted therapy research
Medchemexpress LLC DBCO-PEG4-eosin 5-isothiocyanate | 96.7% | 1228.59 | C50H44Br4N4O11S | 10 MG
DBCO-PEG4-Eosin 5-isothiocyanate is a click-chemistry-enabled fluorescent probe that links a DBCO (dibenzocyclooctyne) reactive group to eosin 5-isothiocyanate via a PEG4 spacer. It is supplied as an orange-red solid for labeling biomolecules using strain-promoted alkyne-azide cycloaddition (SPAAC) and for fluorescence imaging applications.
- Enables copper-free click conjugation via DBCO
- PEG4 spacer improves solubility and reduces steric hindrance
- Eosin 5-isothiocyanate offers red-orange fluorescence for imaging
- High purity suitable for bioconjugation applications
- Supplied in small milligram quantities for research use
- Store sealed, protected from moisture and light; refrigerate for solids
Medchemexpress LLC Propargyl-PEG4-5-nitrophenyl carbonate | 1422540-81-5 | 98.2% | 397.38 | 50 MG
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine-N-azide | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 5 MG
DSPE-N3 is an azide-functionalized distearoyl phosphoethanolamine used as a click-chemistry lipid for bioconjugation and nanoparticle formulation. The amphiphilic molecule presents an azide headgroup that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach alkyne-containing probes, polymers, or targeting ligands, and is commonly applied in liposome and micelle formation, surface functionalization, and targeted delivery research.
- Contains an azide functional group for bioorthogonal click chemistry
- Amphiphilic structure supports liposome and micelle formation
- Suitable for conjugation of alkyne-bearing molecules via CuAAC
- High chemical purity for research-grade applications
- Store sealed at 4°C and protect from moisture for stability
- Available in small lab-scale quantities for formulation work
Medchemexpress LLC Dspe-biotin | 133695-76-8 | 97.5% | 974.36 g/mol | C51H96N3O10PS | 5 MG
DSPE-Biotin is a biotinylated phospholipid designed to introduce biotin functional groups into liposomes, supported lipid bilayers, and other lipid-based systems for labeling, affinity capture, and biochemical assays. It is provided at high purity for research applications and should be handled and stored according to the supplier's recommendations.
- Biotinylated lipid for affinity capture and labeling.
- Compatible with liposome and supported bilayer formulations.
- High purity for reproducible experimental results.
- Soluble in DMSO (≈1.3 mg/mL) with ultrasonic warming to aid dissolution.
- Recommended long-term storage at -20°C protected from light.
- Useful for biochemical assays, surface functionalization, and probe attachment.
Cayman Chemical dPE-PEG 2000-DBCO 10mg
An internal standard for the quantification of betahistine by GC- or LC-MS
Broadpharm Mal-PEG8-NHS ester | 2055033-05-9 | MFCD26127784 | 100mg
Mal-PEG8-NHS ester | Putity: 97% | MW: 618.6 | 2055033-05-9 | MFCD26127784 | 100mg
Medchemexpress LLC Mal-amido-PEG2-Val-Cit-PAB-PNP | 2112738-13-1 | 98.4% | 854.86 g/mol | C39H50N8O14 | 50 MG
Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable two-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs). It contains a val-cit dipeptide cleavable moiety, a p-aminobenzyl (PAB) self-immolative spacer, a para-nitrophenyl (PNP) leaving group, and a maleimide-amido PEG2 spacer for thiol conjugation.
- Cleavable val-cit dipeptide for enzyme-triggered payload release.
- PAB self-immolative spacer enables efficient drug release after cleavage.
- Maleimide-amido PEG2 spacer for thiol-selective conjugation to antibodies.
- High reported purity suitable for research-grade ADC synthesis.
- Available in small research sizes for development and testing.
![eMolecules 604786-74-5 | Biotin-PEG23-amine | Broadpharm | MFCD21363310 | 1299.610 | C58H114N4O25S | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 229582510](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203207.JPG-250.jpg)
eMolecules 604786-74-5 | Biotin-PEG23-amine | Broadpharm | MFCD21363310 | 1299.610 | C58H114N4O25S | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 229582510
Biotin-PEG23-amine | Broadpharm | 604786-74-5 | MFCD21363310 | 1299.610 | C58H114N4O25S | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 229582510