Protein Modification Reagents
Medchemexpress LLC DSPE-pSar50 (DSPE-Polysarcosine50) | 3091879-29-4 | 99.91% | 4319.06 | 5 MG
DSPE-pSar50 (DSPE-Polysarcosine50) is a pSar-lipid derivative that serves as a hydrophilic alternative to PEG. It can be utilized in drug delivery research. The product is for research use only and not sold to patients.
- pSar-lipid derivative
- Hydrophilic alternative to PEG
- Utilized in drug delivery research
- For research use only
eMolecules Fmoc-PEG1-NHS ester | 1807521-05-6 | MFCD28142469 | 1g
Broadpharm | Fmoc-PEG1-NHS ester | 1g | 263744717 | BP-22336 | 98.000 | 1807521-05-6 | MFCD28142469 | 452.463 | C24H24N2O7
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Medchemexpress LLC Fmoc-NH-(PEG)6-CH2CH2COOH | 882847-34-9 | 99.3% | 575.65 | C30H41NO10 | 500 MG
Fmoc-NH-(PEG)6-CH2CH2COOH is an Fmoc-protected PEG6 propionic acid linker used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). It is characterized by high purity, defined molecular properties, and recommended cold storage for stability.
- Cleavable linker for antibody-drug conjugation.
- Fmoc-protected amine functionality for stepwise synthesis.
- PEG6 spacer provides hydrophilicity and flexibility.
- High purity: 99.3%.
- Molecular weight 575.65; formula C30H41NO10.
- Available in multiple sizes: 100 mg, 500 mg, 1 g, 5 g, 10 g.
- Appearance: colorless to light yellow liquid; density 1.202 ± 0.06 g/cm3.
- Storage: -20°C (3 years) or 4°C (2 years) in pure form; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC m-PEG6-CH2CH2COOH | 874208-91-0 | >=95.0% | 368.42 g/mol | C16H32O9 | 500 MG
m-PEG6-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker terminated with a carboxylic acid. It provides a six-unit PEG spacer for flexible linkage in conjugation chemistry and is supplied as a solid for synthetic use. Typical quality: ≥95.0% purity; molecular weight 368.42 g/mol; formula C16H32O9; CAS 874208-91-0.
- Peg6 spacer with terminal carboxylic acid for conjugation.
- Suitable for use as a PROTAC or linker building block in medicinal chemistry.
- Available in multiple pack sizes, including 500 MG.
- High purity for synthetic applications (≥95.0%).
- Solid form with defined molecular weight (368.42 g/mol).
Medchemexpress LLC Pc biotin-peg3-nhs ester | 2353409-93-3 | 95.0% | 840.89 g/mol | C36H52N6O15S | 5 MG
PC Biotin-PEG3-NHS ester is a cleavable three-unit polyethylene glycol (PEG3) linker bearing a biotin tag and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines, used in linker and biotinylation chemistries.
- Cleavable PEG3 linker suitable for conjugation chemistries.
- Contains an NHS ester for efficient reaction with primary amines.
- Biotin tag enables affinity capture and detection.
- Supplied in small, research-scale quantities for synthetic workflows.
- Stable when stored as recommended; purity suitable for research use.
eMolecules N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) | 2100306-62-3 | MFCD30723221 | 500mg
Broadpharm | N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) | 500mg | 343283660 | BP-23585 | 98.000 | 2100306-62-3 | MFCD30723221 | 319.398 | C15H29NO6
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Medchemexpress LLC Mal-amido-PEG8-C2-acid | 1334177-86-4 | MFCD13184956 | 98.7% | 592.63 g·mol-1 | C26H44N2O13 | 250 MG
Mal-amido-PEG8-C2-acid is a maleimide-functionalized PEG8 linker designed for stable, non-cleavable conjugation of payloads to thiol-containing biomolecules. It provides a hydrophilic spacer to improve solubility and reduce aggregation during antibody-drug conjugate and bioconjugation workflows.
- Maleimide group for selective thiol conjugation.
- PEG8 spacer to improve solubility and reduce aggregation.
- Non-cleavable linker to provide stable payload attachment.
- High purity suitable for research and development use (≈98.7%).
- Solid form for straightforward handling and storage.
Medchemexpress LLC Dspe-peg-amine ammonium | 474922-26-4 | 99.5% | 1,000 g/mol (average) | (C2H4O)nN2O10P.NH3 | 250 MG
DSPE-PEG-Amine (average MW 1,000, ammonium salt) is a PEGylated phosphoethanolamine lipid bearing a terminal primary amine. It is formulated for incorporation into liposomes, micelles, and other nanoparticle systems to introduce reactive surface amines for covalent conjugation, targeting ligand attachment, and to provide steric stabilization in delivery research.
- Provides a primary amine terminus for bioconjugation.
- Incorporates into lipid bilayers and micelles for surface functionalization.
- Provides PEG steric stabilization to improve circulation and reduce aggregation.
- Suitable for covalent coupling to proteins, dyes, or targeting ligands.
- Average molecular weight 1,000 g/mol, polymeric PEG repeat unit.
- Recommend frozen, sealed storage and protection from moisture.
Selleck Chemical LLC (S.R.S)-AHPC-PEG4-NH2 hydrochloride S3502-5mg
(S R S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride VHL Ligand-Linker Conjugates 4 hydrochloride E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S R S)-AHPC based VHL ligand and 4-unit PEG linker
Medchemexpress LLC (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy | 2010159-57-4 | 95.6% | 663.83 g/mol | C32H49N5O8S | 10 MG
(S,R,S)-AHPC-PEG4-NH2 is a VHL E3 ligase ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) synthesis. It couples an (S,R,S)-AHPC-derived VHL ligand to a four-unit polyethylene glycol (PEG4) linker terminating in a primary amine, providing a conjugation handle for attachment to target ligands.
- VHL E3 ligase ligand-linker conjugate for PROTAC assembly
- PEG4 linker with terminal primary amine for straightforward conjugation
- Molecular weight 663.83 g/mol
- Typical purity 95.6%; select batches up to 99.51%
- Highly soluble in DMSO (170 mg/mL); ultrasonic agitation recommended
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years)
eMolecules Mal-amido-PEG4-TFP ester | 1807540-84-6 | 250MG | Purity: 98%
Broadpharm | Mal-amido-PEG4-TFP ester | 250MG | 1807540-84-6 | MFCD18791600 | MW:530.83
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Creative Pegworks 4-Arm PEG-MAL, MW 2k - 10g
4-Arm PEG-MAL is a multiarmed PEG derivative with maleimide at each terminal of the four arms connected to one pentaerythritol core. Maleimide selectively reacts with free thiol, SH, sulfhydryl, or mercapto group via Michael addition to form a stable thioether bond. PEG-MAL useful for site specific protein and peptide modification. Hydroquinone MEHQ at ~ 200 ppm may be present as inhibitors to prevent self polymerization and partial crosslinking. MEHQ may be removed per customer request.
eMolecules 17-(amine-PEG9-ethylcarbamoyl)pentanoic t-butyl ester | | | 250mg
Broadpharm | 17-(amine-PEG9-ethylcarbamoyl)pentanoic t-butyl ester | 250mg | 490840976 | BP-24417 | | | | 640.812 | C30H60N2O12
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Medchemexpress LLC Dspe-peg-cooh, mw 2000 | 1403744-37-5 | 100.0% | 2000 Da | C50H94N2NaO14P | 1 MG
DSPE-PEG-COOH (MW 2000) is a PEGylated phospholipid composed of distearoylphosphatidylethanolamine linked to an approximately 2,000 Da polyethylene glycol chain terminating in a carboxylic acid. It is supplied as a white to off-white solid and is used for liposome and nanoparticle formulation and for surface functionalization via amide coupling.
- Terminal carboxylic acid suitable for amide coupling to primary amines.
- Average molecular weight ~2,000 Da provides PEG spacer functionality.
- Facilitates formation of stable, stealth liposomes and nanoparticles.
- White to off-white solid compatible with common organic solvents.
- High reported purity for reproducible formulation and analysis.